Osteoprotegerin: osteo-vascular connection.
نویسنده
چکیده
منابع مشابه
Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice.
BACKGROUND The role of osteoprotegerin in vascular disease is unclear. Recent observational studies show that serum osteoprotegerin levels are associated with the severity and progression of coronary artery disease, atherosclerosis, and vascular calcification in patients. However, genetic and treatment studies in mice suggest that osteoprotegerin may protect against vascular calcification. ME...
متن کاملAssociation of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes
BACKGROUND Osteoprotegerin is a member of the tumor necrosis factor-related family and inhibits RANK stimulation of osteoclast formation as a soluble decoy receptor. The goal of this study was to determine the relationship of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes. METHODS The subjects were 124 patients with type 2 diabetes mellitus, including 88 ma...
متن کاملOsteoprotegerin and Vascular Calcification: Clinical and Prognostic Relevance.
Osteoprotegerin (OPG) is a key regulator in bone metabolism, that also has effect in vascular system. Studies suggest that osteoprotegerin is a critical arterial calcification inhibitor, and is released by endothelial cells as a protective mechanism for their survival in certain pathological conditions, such as diabetes mellitus, chronic kidney disease, and other metabolic disorders. That has b...
متن کاملOsteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification.
OBJECTIVE Mineralization-regulating proteins are found deposited at sites of vascular calcification. However, the relationship between the onset of calcification in vivo and the expression of genes encoding mineralization-regulating proteins is unknown. This study aimed to determine the temporal and spatial pattern of expression of key bone and cartilage proteins as atherosclerotic calcificatio...
متن کاملOsteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression.
BACKGROUND Pulmonary arterial remodeling characterized by increased vascular smooth muscle proliferation is commonly seen in life-threatening disease, pulmonary arterial hypertension (PAH). Clinical studies have suggested a correlation between osteoprotegerin serum levels and PAH severity. Here, we aimed to invhestigate vascular osteoprotegerin expression and its effects on pulmonary arterial s...
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ورودعنوان ژورنال:
- Journal of atherosclerosis and thrombosis
دوره 22 3 شماره
صفحات -
تاریخ انتشار 2015